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Database of Macromolecular Movements
with Associated Tools for Flexibility and Geometric Analysis
This describes the motions that occur in proteins and other macromolecules, particularly using movies. Associated with it are a variety of free software tools and servers for structural analysis. (Citation info)
Databases Servers The database is divided into two sections:
Protein Motions: Manually curated descriptions of conformational changes in hundreds of distinct proteins, with references and movie links. 
Movies: Thousands of morphs of transitions between PDB files, viewable through a Java applet or as MPEG or GIF movies. Most of these are submissions to the Morph Server by database users.
Morph Server: A web-based tool for generating and animating chemically realistic interpolations between two conformations. Now supports RNA, DNA, and multi-subunit complexes. We have also developed new servers for analysis of helix interactions and normal modes of protein domains. 
Hinge Prediction: The new HingeMaster server predicts hinge locations in single protein structures. The algorithm combines FlexOracle, TLSMD, StoneHinge and NSHP hinge predictors for maximum accuracy . Studies and Resources
- The help page gives an overview of the database and citation information. There is also a Morph Server FAQ list.
- View a list of Gerstein lab publications describing applications of the database, or related to protein motions in general.
- Samuel Flores's 2005 article in "The Pharma Frontier" explains molecular motions to the public.
- We have individual pages focusing on membrane protein motions, large-scale protein motions, and protein-protein binding motions
- The highlights page showcases some of our best movies. See especially our movie of the GroEL double ring.
Other useful programs for structure analysis are available for download.
Copyright 1995-2005, M. Gerstein, S. Flores, W. Krebs, N. Echols, and others
This page created by Nat Echols
Last modified April 9, 2006
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